AstraZeneca launches integrated genomics approach to transform drug discovery and development

2016年4月22日

AstraZeneca and its global biologics research and development arm, 落实的, 今天宣布了一项整合基因组计划，以改变其整个研发管道的药物发现和开发.

The initiative includes new collaborations with 人类长寿公司., US; the Wellcome Trust Sanger Institute, UK, and The Institute for Molecular Medicine, Finland. 澳门在线赌城娱乐还将建立一个内部的基因组学研究中心，该中心将开发一个定制的数据库，其中包括临床试验中患者捐赠的样本的基因组序列，以及相关的临床和药物反应数据.

AstraZeneca believes that embedding genomics across its research and development platforms will:

• deliver novel insights into the biology of diseases;
• enable the identification of new targets for medicines;
• support selection of patients for clinical trials;
• allow patients to be matched with treatments more likely to benefit them.

Menelas Pangalos, 执行副总裁, Innovative 药物 & 澳门在线赌城娱乐早期发展部表示:“利用基因组学的力量是澳门第一赌城在线娱乐为患者开发最具创新性和影响力的治疗方法的雄心的基础. With the advent of next generation sequencing and the increased sophistication of data analysis, 现在正是时候，通过这些开创性的合作和建立澳门第一赌城在线娱乐自己的基因组中心，让澳门第一赌城在线娱乐完全融入国际基因组学社区. We will leverage information from up to 2 million genome sequences, 包括500多个,从澳门第一赌城在线娱乐自己的临床试验中, to drive drug discovery and development across all our therapeutic areas. Genomics will be fundamental to our laboratory research, our clinical trials and the launch of our medicines for patients.”

• 人类长寿公司，美国.
  澳门在线赌城娱乐的目标是分享至多500种药物,000份人类长寿DNA样本, 公司, 人类长寿公司将据此对全基因组进行测序，并部署其最先进的机器学习技术, pattern recognition and other analytical techniques. 这些基因组样本将包括那些在澳门在线赌城娱乐临床试验中自愿知情同意的患者捐赠的样本. 澳门在线赌城娱乐还将获得人类长寿公司独特的数据库，该数据库包含多达100万份整合的基因组和健康记录，以增加其分析.

• AstraZeneca’s Centre for Genomics Research
  澳门在线赌城娱乐(AstraZeneca)正在创建一个内部基因组学研究中心(Centre for Genomics Research)，专注于创建和使用一个定制的基因组序列数据库，这些数据库来自过去15年和未来10年在其临床试验中捐赠的患者样本, integrated with associated clinical and drug response data. 除了, 该中心将访问多达500个,000 genomes available through AstraZeneca’s collaborations and from the public domain. 该中心将设在澳门在线赌城娱乐公司位于剑桥的总部，与国际基因组学社区密切合作，从这些前所未有的基因组资源中获得广泛的科学和临床效益.

• The Wellcome Trust Sanger Institute, 剑桥, UK
  AstraZeneca will establish a research team led by a genomics expert of international reputation, embedded within The Wellcome Trust Sanger Institute’s world-renowned Genome Centre in 剑桥, UK. AstraZeneca will share genomic samples and associated clinical data, plus its drug development expertise across core therapy areas. The two parties will identify new targets and biomarkers with potential use in diagnostic tests.

• The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
  AstraZeneca will collaborate with The Institute for Molecular Medicine, Finland and its partners in Finland and the US, to study genes of interest in the Finnish population, which is known to carry a higher than normal frequency of rare variants. 另外, 芬兰有一个由国家生物银行法支持的综合健康记录系统，有助于召回志愿者进行彻底的临床评估.

Bahija Jallal, 执行副总裁, 落实的, 他说:“遗传学和基因组学领域的发展如此迅速，没有一家公司能够将这类研究内部化，并自己完成所有工作. 澳门第一赌城在线娱乐非常清楚这一点, 这就是为什么澳门第一赌城在线娱乐选择与基因组学社区合作，利用基因组分析和大规模基因研究设计方面的外部专业知识. 在一起, with the rich clinical data from our biobank, we will translate these findings into better understanding of disease and ultimately, 为患者提供更有效的治疗.”

In line with AstraZeneca’s “open innovation” approach to research and development, 其基因组平台上所有合作的研究成果将发表在同行评议的期刊上, 促进对疾病遗传影响的更广泛的科学理解，并将澳门在线赌城娱乐定位为全球基因组学研究界的关键参与者.

给编辑的说明

看一个短视频 explaining the genomics platform at AstraZeneca.

关于基因组学
基因组学是对基因组的研究, a double string of DNA which carries all the genes necessary to make and operate an organism. Although most of the information contained in the genome is the same between all individuals, 科学家们认为，许多微小的差异可能与环境影响结合在一起，导致糖尿病等常见疾病, 哮喘或癌症.  研究大量人群的基因组使澳门第一赌城在线娱乐能够更准确地查明这些差异，并开发新的治疗方法，以对抗导致疾病的基因功能异常.

关于人类长寿公司.
人类长寿公司. (HLI)是基于基因组学的, 技术驱动型公司创建世界上最大和最全面的全基因组数据库, 表型和临床数据. HLI正在开发和应用大规模计算和机器学习，以获得新的发现，从而彻底改变医学实践. HLI’s business also includes the HLI Health Nucleus™, a genomic powered clinical research center which uses whole genome sequence analysis, advanced clinical imaging and innovative machine learning, along with curated personal health information, to deliver the most complete picture of individual health. 欲了解更多信息，请访问 http://www.humanlongevity.com or http://www.healthnucleus.com.

About The Wellcome Trust Sanger Institute
The Wellcome Trust Sanger Institute is one of the world's leading genome centres. Through its ability to conduct research at scale, 它能够从事大胆和长期的探索性项目，旨在影响和增强全球医学科学. 研究所研究成果, 通过其自己的研究项目和在国际财团中的领导作用而产生, are being used to develop new diagnostics and treatments for human disease. http://www.sanger.ac.uk/

About The Institute for Molecular Medicine Finland (FIMM), University of Helsinki
芬兰分子医学研究所(FIMM)是一家位于赫尔辛基的国际研究机构，专注于人类基因组学和个性化医学. FIMM integrates molecular medicine research, 技术中心和生物银行基础设施“在一个屋檐下”，从而促进转化研究和采用个性化医疗保健. FIMM由赫尔辛基大学主办，是北欧EMBL分子医学伙伴关系以及EU-Life网络的一部分.  In 2015, FIMM had a staff of 200 and a budget of 17 million €, with competitive external funding accounting for a significant part of the budget. www.菲姆.fi / en /

关于美
落实的 is the global biologics research and development arm of AstraZeneca, 一个全球, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of small molecule and biologic prescription medicines. 落实的正在开拓创新研究和探索跨关键治疗领域的新途径, 包括呼吸, 炎症 and autoimmunity; cardiovascular and 代谢 disease; 肿瘤学; neuroscience; and infection and vaccines. The 落实的 headquarters is located in 盖瑟斯堡, Md.澳门在线赌城娱乐全球三大研发中心之一&D centers, with additional sites in 剑桥, UK and Mountain View, CA. 欲了解更多信息，请访问 www.落实的.com

关于澳门在线赌城娱乐
澳门在线赌城娱乐是一家全球性的, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of cardiovascular, 代谢, 呼吸, 炎症, 自身免疫性, 肿瘤学, 感染和神经系统疾病. 澳门在线赌城娱乐在100多个国家开展业务，其创新药物被全球数百万患者使用. 欲知详情，请浏览: www.澳门在线赌城娱乐.com

联系人

关键字:RIA -呼吸，炎症和自身免疫，CVMD -心血管和代谢疾病，

ING - Infection, Neuroscience and Gastrointestinal