癌症联合治疗:
寻求更深刻、更持久的回应

写的:

随着癌症的发展, its complexity and heterogeneity increases along with its ability to develop resistance to cancer treatments. 为患者带来益处，实现长期生存, 重要的是，澳门第一赌城在线娱乐要及早治疗癌症，找到针对其弱点的多模式方法. 在澳门在线赌城娱乐, 澳门第一赌城在线娱乐多样化的药物组合在设计时就考虑到了这一点, 重点是挑战耐药性的组合, 并且有可能引出更深层次的问题, 更持久的反应.

为什么在癌症中使用联合治疗?

Monotherapy – killing cancer cells with a single pharmaceutical agent – plays a key role in cancer treatment, 为许多患者带来益处. 然而, 澳门第一赌城在线娱乐可以做更多的事情来应对诊所中持续存在的挑战, 比如耐药性和治疗的副作用.

Combining two or more agents to target aspects of cancer growth and survival has emerged as a key opportunity for driving progress – by developing treatment regimens which target independent molecular pathways, 癌症联合治疗的目的是:

• 地址的复杂性每种肿瘤在基因上都是独一无二的, 表观遗传学和蛋白质组学细节, and cells within a single tumour are heterogeneous and often respond to treatment differently. 针对癌细胞亚群的癌症联合疗法, 提供一种微妙的方法来针对复杂的肿瘤生物学.
• 克服阻力: A strategic combination of medicines can hinder the tumours’ ability to develop resistance, 并可能提高患者的治疗效果.
• 提高治疗反应联合治疗有可能增加癌细胞的死亡, 与单一疗法相比，会产生更深刻、更持久的反应.

到目前为止，澳门第一赌城在线娱乐已经看到癌症联合疗法取得了一些真正的成功, 这通常是缓慢和线性的, 在现有的癌症治疗方法中加入一种新的癌症药物. 在澳门在线赌城娱乐, 澳门第一赌城在线娱乐遵循科学来指导澳门第一赌城在线娱乐的组合方法, 有多种多样的组合设计从多个角度攻击癌症.

癌症联合治疗的协同效应之外的思考

The concept of synergy – clinical activity of two agents exceeding addition of their individual effects – has long been a major driver in the design of cancer combination therapies. 虽然它有强大的治疗潜力, 制定这些方案也可能面临挑战, 比如协同生物学可能产生的有害副作用. 进一步, reliance on synergistic mechanisms can also lead to unexpected vulnerabilities to 耐药性, 比如降低治疗的持久性. 例如，澳门第一赌城在线娱乐的研究发表在 发现血癌¹ investigated the role of synergy in the development of resistance to combination therapy in human leukaemia cell lines. The study revealed for the first time an experimental relationship between synergy and an increased likelihood of developing tumour resistance, 先前研究提出的效应^2-5, and suggests cancer combination therapies that depend primarily on synergy may have less durable responses.

澳门第一赌城在线娱乐现在开始提出大胆的问题来挑战肿瘤学的传统, 解决出现的治疗耐药性问题, and tackle the side effects which often make dosing cancer combinations at the intended dose difficult. 通过多角度攻击癌症, 使用多种模式, 通过联合用药可以获得更有意义的临床结果. 澳门第一赌城在线娱乐的肿瘤产品组合旨在实现这一战略, 包括精准医疗，如: 抗体药物偶联物 (adc), 靶向多种肿瘤生物学机制的小分子抑制剂, 还有免疫肿瘤药物. Combinations of these agents have the potential to allow targeting multiple disease drivers simultaneously, 最大限度地提高预期的治疗效果，并尽量减少潜在的耐药性.

澳门第一赌城在线娱乐在寻找新的方法来帮助病人, we’re thinking strategically and following the science to enable these multimodal combinations which can be scheduled to target more than one aspect of complex cancer biology, 有了目标才能实现得更深, 以及更持久的反应.

寻找精准医疗时代的战略组合

当澳门第一赌城在线娱乐在肿瘤学组合的思考中拓宽了澳门第一赌城在线娱乐的视野，超越了协同作用, 澳门第一赌城在线娱乐需要一种方法来指导澳门第一赌城在线娱乐确定它们的优先次序和发展.

为了解决这个问题, 澳门第一赌城在线娱乐的联合发现工作集中在寻找合适剂量的药物, 在合适的病人身上, 并且具有可接受的安全性, with the overall aim to attack a tumour from multiple angles and drive deeper responses in the clinic.

澳门第一赌城在线娱乐现在使用的模型系统可以更好地捕捉肿瘤的异质性, 例如患者来源的异种移植物和类器官, 以帮助确定澳门第一赌城在线娱乐的组合策略. By enhancing our preclinical and translational understanding of underlying disease mechanisms and biomarkers, better predicting combination tolerability and identifying the right dose schedules - we are answering critical questions which help us deliver combination therapies in the clinic. 

澳门第一赌城在线娱乐的研究发表在 癌症的发现,⁶ illustrates how large-scale combination screens can be mined differently to prioritise targeted combinations most likely to benefit specific patient populations. Rather than focusing on the combinations which elicited the broadest and highest “synergy scores”, we took a holistic approach to prioritising combinations: looking for those that not only demonstrate activity above monotherapy, 但也表现出对特定癌症类型和遗传背景的选择性. 通过这种方法, 澳门第一赌城在线娱乐能够成功地识别和验证新的组合假设, 同时优化临床可译性. 澳门第一赌城在线娱乐实现这一目标的方法之一是使用 multi-omics数据, which identified emergent biomarkers that can predict unique responses to combination treatments.

Our novel experimental and analytical approach is one of the largest published combination screens to date and will also help future artificial intelligence approaches to identify new cancer combinations for therapies and biomarkers of response.

通过采取精准医疗的方法, our innovative framework takes us a step closer to designing combination therapies based on each patient's unique response potential. It provides valuable insights early in drug development and allows us to test how different modalities work together, 最终提高患者预后改善的机会.

释放联合治疗的全部潜力:癌症治疗的发展

在过去, 肿瘤学家在逐步建立联合疗法方面取得了巨大成功, 在现有疗法的基础上增加新疗法. 科技的进步让澳门第一赌城在线娱乐对癌症有了前所未有的了解, 使澳门第一赌城在线娱乐能够加速这一进程, 更快地设计和评估创新的癌症联合疗法, 而且更加精确.

澳门第一赌城在线娱乐继续挑战传统是很重要的, 利用反映癌症复杂性的模型系统, 并努力提高澳门第一赌城在线娱乐对耐药性机制的理解. 通过这样做, we have the potential to develop smarter combination strategies and attack cancer from multiple angles – bringing us a step closer to one day eliminating cancer as a cause of death.

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